Two sample MR report
KANSL1-AS1_Endothelial Cell (Endo) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 44 | -0.0048115 | 0.0149045 | 0.7484321 |
| Weighted median | 44 | 0.0149604 | 0.0023131 | 0.0000000 |
| Inverse variance weighted | 44 | 0.0133332 | 0.0016328 | 0.0000000 |
| Simple mode | 44 | 0.0151220 | 0.0044154 | 0.0013637 |
| Weighted mode | 44 | 0.0150393 | 0.0043984 | 0.0013857 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.53134 | 42 | 0.9998543 |
| Inverse variance weighted | 18.03140 | 43 | 0.9997149 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0243053 | 0.0198448 | 0.2274875 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0007007 | 0 | TRUE | 0.0120793 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
